GTS GTS-2 IMMEDIAS VZGLYAD BIOSFERA LEGO LSO LSO-B LSO-S LSO-H POPULAR MECHANICS MPAC & SEED HDTV STARMAIL GCF-JAXA (NASDA) ROKVISS ETD NEUROCOG CARDIOCOG NEUROCOG-3 JAXA 3DPC JAXA 3DPC-2 SCN CARDIOCOG-4 NOA IMMUNO GOLF MYOCITE STROMA AMPHIBODY TUBUL MIA NKA BIOCULTURE ALTCRISS CULT Pille-ISS MATRIX Z1 Sample-LDM AT-SPACE BIOKIN 4 PKINASE EXPOSE-R

 
homepage
INTERNATIONAL SPACE STATION
EXPERIMENTS AND RESEARCHES
SCIENCE RESEARCH ON ISS RUSSIAN SEGMENT
CONTRACT ACTIVITIES
"STROMA"
Principal Investigators: S, University of Genova (Switzerland)
Research Manager: Dr. R. Candedda

russian
   

USED SCIENCE HARDWARE:

  • KUBIK 1 incubator with the power cable;
  • Stroma Biocontainers (10);

  • Cryogem-03M refrigerator/temperature controller container

CONSUMABLES:

  • Biokit 3

 

PURPOSE:

Investigate the bone marrow stromal cell differentiation and mesenchymal tissue reconstruction in microgravity.

OBJECTIVES:

Assess the microgravity effects on mesenchymal Bone Marrow Stromal Cells.

EXPERIMENT RESULTS:

Biology containers (10) returned to the ground.

EXPECTED RESULTS:

The investigation results may help to better understand the bone-loss in microgravity, which may be considered as an accelerated experimental osteoporosis model.

 

Bone loss, decreased bone density and de-calcification are one the major physiological weaknesses observed during long-duration spaceflight, this is mainly connected to the lack, or greatly reduced, mechanical loads exerted on bones in microgravity. However, it remains to be verified whether bone loss is due to a decreased synthesis (osteoblastic activity), or to an increased resorption (osteoclastic activity), or to both. Alterations in the proliferative answer and in the differentiation of the osteoblasts and/or osteoclasts or of their precursors (in the bone marrow) may explain the microgravity catabolic effects on bone tissue.
This experiment will assess the microgravity effects on mesenchymal Bone Marrow Stromal Cells, which contain a very active fraction of multipotents bone-cells precursors. Results may help to better understand the bone-loss in microgravity, which may be considered as an accelerated experimental osteoporosis model.

 

 

 

 

Official WEB-site of S.P.Korolev RSC Energia
E-mail:mail@rsce.ru