GTS GTS-2 IMMEDIAS VZGLYAD BIOSFERA LEGO LSO LSO-B LSO-S LSO-H POPULAR MECHANICS MPAC & SEED HDTV STARMAIL GCF-JAXA (NASDA) ROKVISS ETD NEUROCOG CARDIOCOG NEUROCOG-3 JAXA 3DPC JAXA 3DPC-2 SCN CARDIOCOG-4 NOA IMMUNO GOLF MYOCITE STROMA AMPHIBODY TUBUL MIA NKA BIOCULTURE ALTCRISS CULT Pille-ISS MATRIX Z1 Sample-LDM AT-SPACE BIOKIN 4 PKINASE EXPOSE-R

 
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INTERNATIONAL SPACE STATION
EXPERIMENTS AND RESEARCHES
SCIENCE RESEARCH ON ISS RUSSIAN SEGMENT
CONTRACT ACTIVITIES
EXPERIMENT "MYOCITE"
Principal Investigators: ESA, University of Bordeaux (France)
Research Manager: Dr. J.L. Morel and è J. Mironneau

russian
   

USED SCIENCE HARDWARE:

  • KUBIK 1 incubator with the power cable;
  • Myocite Biocontainers (8);

  • Cryogem-03M refrigerator/temperature controller container

CONSUMABLES:

  • Biokit 2

  

PURPOSE:

Characterize the effect of microgravity on the expression of calcium channels in Myocytes.

OBJECTIVES:

  • Determine effect of “short duration” (2d) microgravity exposure on Myocyte calcium channel expression
  • Determine if Myocyte calcium channel expression adapts during “long duration” (7d) exposure to microgravity.
EXPERIMENT RESULTS:

Biology containers returned to the ground.

EXPECTED RESULTS:

This experiment will help in understanding how microgravity modulates the function of vascular myocytes, which is relevant to crew health issues
 

Vascular hyporeactivity (loss of vascular muscle tone) is a major health problem in the elderly and sedentary people. This can be manifested as a loss of consciousness during a quick position change (inorthostatic intolerence). Vascular hyporeactivity is also a problem for astronauts following spaceflight.
In animal models it has been shown that vascular hyporeactivity is linked to hyporeactivity of muscle cells in the vascular wall. The reactivity of vascular muscle cells is controlled by calcium fluxes through calcium channels on the muscle cells.
In animal models it has been shown that vascular hyporeactivity is linked to hyporeactivity of muscle cells in the vascular wall. The reactivity of vascular muscle cells is controlled by calcium fluxes through calcium channels on the muscle cells.
The experiment will investigate the expression of calcium channels in rat cardiac myocytes under microrgravity. The expression following “short duration” (1 day) and “long duration” (7 day) exposure to microgravity will be compared to the expression of control cells under 1g.

 

 

 

 

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